• Users Online: 277
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
PERSPECTIVE
Year : 2021  |  Volume : 26  |  Issue : 1  |  Page : 52-55

Need for abundant caution in prophylactic application of chloroquine and hydroxychloroquine for viral infections including COVID-19: Possibility of increased susceptibility


Samsung Health Division, Samsung Research Institute, Noida, Uttar Pradesh, India

Correspondence Address:
Ritesh Singh
Samsung Health Division, Samsung Research Institute, Noida, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmgims.jmgims_36_20

Rights and Permissions

Significant interest in the application of chloroquine (CQ) and hydroxychloroquine (HCQ) for prophylaxis and treatment of COVID-19 has been recently reported throughout the world. In the light of this, it has become important to revisit the mechanisms of action, as well as clinical evidence for the efficacy of CQ and HCQ in similar viral infections. We note that while some evidence exists for therapeutic efficacy of CQ and HCQ in mitigating morbidities associated with virus-induced inflammation and immunohyperactivity, abundant caution is necessary for expecting prophylactic efficacy in the light of therapeutic evidence. In particular, we intend to draw urgent attention to the fact that the same immunosuppresive and immunomodulatory properties of CQ and HCQ which render them useful as therapeutic agents in viral pneumonia and cytokine storm syndrome are also expected to make them dangerous prophylactic agents against viral infections. We also intend to draw attention to some other potential concerns associated with widespread prophylactic usage of CQ and HCQ.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed402    
    Printed4    
    Emailed0    
    PDF Downloaded114    
    Comments [Add]    

Recommend this journal