Journal of Mahatma Gandhi Institute of Medical Sciences

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 26  |  Issue : 1  |  Page : 11--17

Intrathecal isobaric 1% 2-chloroprocaine versus hyperbaric 0.5% bupivacaine in parturients undergoing lower segment cesarean section: A randomized controlled trial


Neena Jain, Kavita Jain, Harshita Prajapat, Surendra Kumar Sethi, Veena Patodi, Arvind Khare 
 Department of Anaesthesiology, Jawahar Lal Nehru Medical College and Associated Group of Hospitals, Ajmer, Rajasthan, India

Correspondence Address:
Dr. Surendra Kumar Sethi
Flat No. 202, Shiv Enclave, Civil Lines, Ajmer, Rajasthan
India

Background: Cesarean sections are usually done under spinal anesthesia (SA) using local anesthetics. This study is aimed to compare the efficacy of intrathecal isobaric 1% 2-chloroprocaine (CP) and hyperbaric 0.5% bupivacaine in parturients undergoing lower segment cesarean section (LSCS). Materials and Methods: One hundred parturients aged 18–35 years with the American Society of Anesthesiologists physical status I or II undergoing LSCS were randomly allocated into two groups. Group A (n = 50) received intrathecal isobaric 1% 2-CP 5 ml (50 mg), while Group B (n = 50) received intrathecal hyperbaric 0.5% bupivacaine 2 ml (10 mg) in SA. Onset and duration of both sensory and motor block, highest dermatomal level achieved, time to achieve highest dermatomal level, two-segment regression, duration of analgesia, hemodynamic changes, and side effects were noted. Results: The onset of sensory blockade was significantly faster in Group A (1.66 ± 0.49 min) compared to Group B (3.00 ± 0.58 min) (P < 0.05). Duration of sensory block was significantly shorter in Group A (P < 0.05). The time of two-segment regression was also significantly faster in Group A (41.44 ± 5.41 min) compared to Group B (70.24 ± 10.38 min) (P < 0.05). The onset time of the motor block was significantly faster in Group A (P < 0.05). Duration of motor blockade was significantly shorter in Group A (95.7 ± 9.8 min) as compared to Group B (186.26 ± 13.5 min) (P < 0.05). Duration of analgesia was significantly shorter in Group A (97.22 ± 11.82 min) when compared to Group B (191.58 ± 37.06 min) (P < 0.05). No significant hemodynamic changes and side effects were noted (P > 0.05). Conclusion: Intrathecal 1% 2-CP (50 mg) appears to be a safe and effective alternative, preferably in elective and uncomplicated LSCS, as it has faster onset and predictable sensory block height with shorter but adequate duration of motor block and analgesia.


How to cite this article:
Jain N, Jain K, Prajapat H, Sethi SK, Patodi V, Khare A. Intrathecal isobaric 1% 2-chloroprocaine versus hyperbaric 0.5% bupivacaine in parturients undergoing lower segment cesarean section: A randomized controlled trial.J Mahatma Gandhi Inst Med Sci 2021;26:11-17


How to cite this URL:
Jain N, Jain K, Prajapat H, Sethi SK, Patodi V, Khare A. Intrathecal isobaric 1% 2-chloroprocaine versus hyperbaric 0.5% bupivacaine in parturients undergoing lower segment cesarean section: A randomized controlled trial. J Mahatma Gandhi Inst Med Sci [serial online] 2021 [cited 2021 Nov 28 ];26:11-17
Available from: https://www.jmgims.co.in/article.asp?issn=0971-9903;year=2021;volume=26;issue=1;spage=11;epage=17;aulast=Jain;type=0